A young American woman moves with her husband to Bucharest, and begins to suspect that a stranger who watches her from the apartment building across the street may be a local serial killer decapitating women.

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In a state-of-the-art penitentiary run by brilliant visionary Steve Abnesti (Chris Hemsworth), inmates wear a surgically attached device that administers dosages of mind-altering drugs in exchange for commuted sentences. There are no bars, no cells, or orange jumpsuits. In Spiderhead, incarcerated volunteers are free to be themselves. Until they're not. At times, they're a better version. Need to lighten up? There's a drug for that. At a loss for words? There's a drug for that, too. But when two subjects, Jeff (Miles Teller) and Lizzy (Jurnee Smollett), form a connection, their path to redemption take a twistier turn, as Abnesti's experiments start to push the limits of free will altogether.

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